A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model.

Is it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip?Multi-organ-chip co-cultures of human liver and testis equivalents were maintained at a steady-state for at least 1 week and the co-cultures reproduced specific natural and drug-induced liver-testis systemic interactions.

Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
DLR-ADAMTS4-Hu-48T	DL Develop	48T	EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
DLR-ADAMTS4-Hu-96T	DL Develop	96T	EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
DLR-ADAMTS4-Ra-48T	DL Develop	48T	EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rat A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
DLR-ADAMTS4-Ra-96T	DL Develop	96T	EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
RDR-ADAMTS4-Hu-48Tests	Reddot Biotech	48 Tests	EUR 544

Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
RDR-ADAMTS4-Hu-96Tests	Reddot Biotech	96 Tests	EUR 756

Rat A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
RDR-ADAMTS4-Ra-48Tests	Reddot Biotech	48 Tests	EUR 583

Rat A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) ELISA Kit
RDR-ADAMTS4-Ra-96Tests	Reddot Biotech	96 Tests	EUR 811

Anti-ADAMTS4/ADAMTS4 Antibody
PA1479	BosterBio	100ug/vial	EUR 294

Anti-ADAMTS4/ADAMTS4 Antibody
A02899	BosterBio	100ug/vial	EUR 334

Adamts4/ Rat Adamts4 ELISA Kit
ELI-05836r	Lifescience Market	96 Tests	EUR 886

ADAMTS4 Antibody
1-CSB-PA001311LA01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against ADAMTS4. Recognizes ADAMTS4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

ADAMTS4 Antibody
32691-100ul	SAB	100ul	EUR 252

ADAMTS4 siRNA
20-abx900171	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

ADAMTS4 siRNA
20-abx906769	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

ADAMTS4 siRNA
20-abx906770	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

ADAMTS4 Antibody
ABD6986	Lifescience Market	100 ug	EUR 438

ADAMTS4 Antibody
DF6986	Affbiotech	200ul	EUR 304
Description: ADAMTS4 Antibody detects endogenous levels of total ADAMTS4.

anti-ADAMTS4
YF-PA16352	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to ADAMTS4

anti-ADAMTS4
YF-PA16353	Abfrontier	100 ul	EUR 403
Description: Rabbit polyclonal to ADAMTS4

anti-ADAMTS4
YF-PA16354	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to ADAMTS4

ADAMTS4 antibody
70R-2304	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal ADAMTS4 antibody raised against the N terminal of ADAMTS4

ADAMTS4 antibody
70R-14018	Fitzgerald	100 ug	EUR 322
Description: Affinity purified Rabbit polyclonal ADAMTS4 antibody

ADAMTS4 cloning plasmid
CSB-CL001311HU-10ug	Cusabio	10ug	EUR 233
Description: A cloning plasmid for the ADAMTS4 gene.

Anti-ADAMTS4 antibody
STJ117315	St John's Laboratory	100 µl	EUR 277
Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Anti-ADAMTS4 antibody
STJ22510	St John's Laboratory	100 µl	EUR 277
Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

ADAMTS4 Polyclonal Antibody
A50013	EpiGentek	100 µg	EUR 570.55
Description: fast delivery possible

ADAMTS4 Rabbit pAb
A2525-100ul	Abclonal	100 ul	EUR 308

ADAMTS4 Rabbit pAb
A2525-200ul	Abclonal	200 ul	EUR 459

ADAMTS4 Rabbit pAb
A2525-20ul	Abclonal	20 ul	EUR 183

ADAMTS4 Rabbit pAb
A2525-50ul	Abclonal	50 ul	EUR 223

ADAMTS4 Rabbit pAb
A15121-100ul	Abclonal	100 ul	EUR 308

ADAMTS4 Rabbit pAb
A15121-200ul	Abclonal	200 ul	EUR 459

ADAMTS4 Rabbit pAb
A15121-20ul	Abclonal	20 ul	EUR 183

ADAMTS4 Rabbit pAb
A15121-50ul	Abclonal	50 ul	EUR 223

ADAMTS4 Conjugated Antibody
C32691	SAB	100ul	EUR 397

ADAMTS4 Blocking Peptide
DF6986-BP	Affbiotech	1mg	EUR 195

Anti-ADAMTS4 (2A6)
YF-MA16887	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to ADAMTS4

ADAMTS4 Blocking Peptide
33R-3654	Fitzgerald	100 ug	EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ADAMTS4 antibody, catalog no. 70R-2304

ADAMTS4 Antibody, HRP conjugated
1-CSB-PA001311LB01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against ADAMTS4. Recognizes ADAMTS4 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

ADAMTS4 Antibody, FITC conjugated
1-CSB-PA001311LC01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against ADAMTS4. Recognizes ADAMTS4 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

ADAMTS4 Antibody, Biotin conjugated
1-CSB-PA001311LD01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against ADAMTS4. Recognizes ADAMTS4 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Anserini ADAMTS4 ELISA Kit
EAD0023	Abclonal	96Tests	EUR 521

Rat ADAMTS4 ELISA Kit
ERD0023	Abclonal	96Tests	EUR 521

Rabbit ADAMTS4 ELISA Kit
ERTD0023	Abclonal	96Tests	EUR 521

Mouse ADAMTS4 ELISA Kit
EMD0023	Abclonal	96Tests	EUR 521

Porcine ADAMTS4 ELISA Kit
EPD0023	Abclonal	96Tests	EUR 521

Human ADAMTS4 ELISA Kit
EHD0023	Abclonal	96Tests	EUR 521

Canine ADAMTS4 ELISA Kit
ECD0023	Abclonal	96Tests	EUR 521

Goat ADAMTS4 ELISA Kit
EGTD0023	Abclonal	96Tests	EUR 521

Bovine ADAMTS4 ELISA Kit
EBD0023	Abclonal	96Tests	EUR 521

Polyclonal ADAMTS4 Antibody (Internal)
APR01979G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADAMTS4 (Internal). This antibody is tested and proven to work in the following applications:

Polyclonal ADAMTS4 Antibody (Internal)
APR01980G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADAMTS4 (Internal). This antibody is tested and proven to work in the following applications:

Rat ADAMTS4 shRNA Plasmid
20-abx986451	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse ADAMTS4 shRNA Plasmid
20-abx982484	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Human ADAMTS4 shRNA Plasmid
20-abx956314	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse Adamts4 ELISA KIT
ELI-05835m	Lifescience Market	96 Tests	EUR 865

Human ADAMTS4 ELISA KIT
ELI-05837h	Lifescience Market	96 Tests	EUR 824

Bovine ADAMTS4 ELISA KIT
ELI-05838b	Lifescience Market	96 Tests	EUR 928

Bovine ADAMTS4 ELISA KIT
ELI-06741b	Lifescience Market	96 Tests	EUR 928

ADAMTS4 ELISA KIT|Human
EF006049	Lifescience Market	96 Tests	EUR 689

Human ADAMTS4 ELISA Kit
ELA-E1804h	Lifescience Market	96 Tests	EUR 824

Guinea Pig ADAMTS4 ELISA Kit
EGD0023	Abclonal	96Tests	EUR 521

Polyclonal ADAMTS4 Antibody (Metalloprotease Domain)
APR02063G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADAMTS4 (Metalloprotease Domain). This antibody is tested and proven to work in the following applications:

ADAMTS4 Polyclonal Antibody, HRP Conjugated
A50014	EpiGentek	100 µg	EUR 570.55
Description: reagents widely cited

ADAMTS4 Polyclonal Antibody, FITC Conjugated
A50015	EpiGentek	100 µg	EUR 570.55
Description: Ask the seller for details

ADAMTS4 Polyclonal Antibody, Biotin Conjugated
A50016	EpiGentek	100 µg	EUR 570.55
Description: The best epigenetics products

ADAMTS4 ELISA Kit (Human) (OKCD09242)
OKCD09242	Aviva Systems Biology	96 Wells	EUR 975
Description: Description of target: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.115ng/mL

ADAMTS4 ELISA Kit (Rat) (OKCD09243)
OKCD09243	Aviva Systems Biology	96 Wells	EUR 1053
Description: Description of target: Adamts4 is a disintegrin and metalloproteinase; Adamts4 may play a role in the progression of Alzheimers disease.;Species reactivity: Rat;Application: ELISA;Assay info: ;Sensitivity: < 0.056ng/mL

ADAMTS4 ELISA Kit (Rabbit) (OKCD09244)
OKCD09244	Aviva Systems Biology	96 Wells	EUR 1053
Description: Description of target: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.;Species reactivity: Rabbit;Application: ELISA;Assay info: ;Sensitivity: < 12.1pg/mL

ADAMTS4 ELISA Kit (Rat) (OKEH03412)
OKEH03412	Aviva Systems Biology	96 Wells	EUR 662
Description: Description of target: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 40.4 pg/mL

ADAMTS4 ELISA Kit (Mouse) (OKEH05322)
OKEH05322	Aviva Systems Biology	96 Wells	EUR 662
Description: Description of target: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.335 ng/mL

ADAMTS4 ELISA Kit (Human) (OKAN04996)
OKAN04996	Aviva Systems Biology	96 Wells	EUR 792
Description: Description of target: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.115 ng/mL

ADAMTS4 ELISA Kit (Human) (OKBB00627)
OKBB00627	Aviva Systems Biology	96 Wells	EUR 505
Description: Description of target: ADAMTS4, A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. The human ADAMTS4 gene is mapped to chromosome 1 by somatic cell hybrid analysis. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 20 pg/mL

ADAMTS4 ELISA Kit (Bovine) (OKEH08427)
OKEH08427	Aviva Systems Biology	96 Wells	EUR 1092
Description: Description of target: ;Species reactivity: Bovine;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity:

ELISA kit for Human ADAMTS4
EK5635	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human ADAMTS4 in samples from serum, plasma, tissue homogenates and other biological fluids.

ADAMTS4 ORF Vector (Human) (pORF)
ORF000180	ABM	1.0 ug DNA	EUR 95

Adamts4 ORF Vector (Mouse) (pORF)
ORF038112	ABM	1.0 ug DNA	EUR 506

Adamts4 ORF Vector (Rat) (pORF)
ORF063070	ABM	1.0 ug DNA	EUR 506

ADAMTS4 sgRNA CRISPR Lentivector set (Human)
K0043901	ABM	3 x 1.0 ug	EUR 339

Adamts4 sgRNA CRISPR Lentivector set (Mouse)
K4671601	ABM	3 x 1.0 ug	EUR 339

Adamts4 sgRNA CRISPR Lentivector set (Rat)
K6971301	ABM	3 x 1.0 ug	EUR 339

ADAMTS4 ELISA Kit (Human) : 96 Wells (OKEH02632)
OKEH02632	Aviva Systems Biology	96 Wells	EUR 662
Description: Description of target: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.092 ng/mL

ADAMTS4 sgRNA CRISPR Lentivector (Human) (Target 1)
K0043902	ABM	1.0 ug DNA	EUR 154

ADAMTS4 sgRNA CRISPR Lentivector (Human) (Target 2)
K0043903	ABM	1.0 ug DNA	EUR 154

ADAMTS4 sgRNA CRISPR Lentivector (Human) (Target 3)
K0043904	ABM	1.0 ug DNA	EUR 154

Adamts4 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4671602	ABM	1.0 ug DNA	EUR 154

Adamts4 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4671603	ABM	1.0 ug DNA	EUR 154

Adamts4 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4671604	ABM	1.0 ug DNA	EUR 154

Adamts4 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6971302	ABM	1.0 ug DNA	EUR 154

Adamts4 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6971303	ABM	1.0 ug DNA	EUR 154

Adamts4 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6971304	ABM	1.0 ug DNA	EUR 154

ADAMTS4 Protein Vector (Human) (pPB-His-MBP)
PV319886	ABM	500 ng	EUR 329

ADAMTS4 Protein Vector (Human) (pPB-His-GST)
PV319887	ABM	500 ng	EUR 329

ADAMTS4 Protein Vector (Rat) (pPB-C-His)
PV252278	ABM	500 ng	EUR 1166

ADAMTS4 Protein Vector (Rat) (pPB-N-His)
PV252279	ABM	500 ng	EUR 1166

Current benchtop reprotoxicity models typically do not include hepatic metabolism and interactions of the liver-testis axis. However, these are important to study the biotransformation of substances.

Testicular organoids derived from primary adult testicular cells and liver spheroids consisting of cultured HepaRG cells and hepatic stellate cells were loaded into separate culture compartments of each multi-organ-chip circuit for co-culture in liver spheroid-specific medium, testicular organoid-specific medium or a combined medium over a week.