Visible light irradiation is an emerging area in regenerative medicine research. We hypothesized that low intensity pulsed LED light irradiance may exert photobiomodulatory effects on cultured osteoblast-like cells.
To test this hypothesis, we investigated cell proliferation and markers of cell maturation and metabolic activity following pulsed LED irradiance.
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Monolayer explant cultures of human osteoblast-like cells were exposed four times in 24-hour intervals to 2 minutes of pulsed white LED irradiance of 2.4-2.5 mW/cm2 and its different spectra of 0.2-0.5 mW/cm2 (frequency range of 10-40 Hz).